Two evidence-based articles for Major Depressive Disorder Opinions and recommendations are supported with references from the literature. Two evidence-based articles has been used to support the treatment plan. All references must be less than 5 years old. Diagnosis: Major Depressive Disorder Chronic treatment plan choices: 1, Stress management and lifestyle changes, such as regular exercise, which have been found to decrease depression, are essential, are ongoing prevention. 2, Behavioral therapy involves various relaxation techniques, self-care strategies, and cognitive and dialectical therapy may also be helpful. Studies suggest that augmentation of antidepressant effect occurs with adjunct use of omega-3 fish oil supplements, 1000 mg twice daily. B vitamin supplementation has also been used in some studies, with equivocal results.